New Jersey / Karachi: A team of scientists at Princeton University in the United States has developed a drug (antibiotic) that can act like a “molecular poison arrow” and kill any type of bacteria, no matter how severe. Why not What’s even more interesting is that, unlike conventional antibiotics, germs are not resistant to this drug. So far it has been tested on mice, but it could take at least eight years for it to become commercially available after human trials.
The latest online publication of the research journal “Cell” details the breakthrough, which shows that the drug works in a very different way than normal antibiotics. It is made by modifying the molecules of SCH 79797, a compound that has been used in the medical industry for years, and is named Irresistin-16.
SCH 79797 is a toxic substance that is used for specific medical purposes only after taking special precautions. It is known that it can kill any cell, no matter how hard it is. Concerned about the growing resistance of germs to antibiotics, scientists and researchers have their eyes on the compound, but they do not know how it works and kills any kind of cell, including germs. Does
Princeton University experts were the first to answer that question. After many years of research, they finally came to know that the molecule of SCH 79797 has two properties at the same time: it is sharp like an arrow and at the same time it is poisonous.
When it attacks a living cell, it first takes advantage of its arrow-like structure to tear the cell membrane and enters, initiating its destruction.
Once inside the cell, the same molecule uses its venom and blows up the “folate” fragments that are key to the structure of DNA / RNA. In this way, it kills the living cells or germs.
The difficulty, however, was that SCH 79797 kills both harmless cells and microbes with equal brutality, while for the drug to be used it must target only specific microbes and not harm other cells. ۔
After understanding the mechanism of action of SCH 79797, the experts did further research and changed it to develop an antibiotic called “Errstein 16”. Initially, it was successfully tested against harmful microorganisms ranging from E. coli to the so-called MRSA.
These experiments showed that Erzestan was about 1,000 times more deadly to 16 microbes than human cells. In addition, the most important revelation during this time was that there was no resistance to any kind of germs against Erzestan 16 even after several generations; it was certainly a great achievement.
In the next step, it was tested on mice infected with a type of highly virulent bacterium. In these experiments, Errstein 16 completely eliminated the microbes, but did little damage to other healthy mouse cells.
Researchers on antibiotics have called it a “revolutionary breakthrough” and said that “antibiotics like poison arrows” have opened a new chapter in the possibilities of treating diseases.
The next step is the clinical trials of this new type of antibiotic, the subject of which is subject to FDA approval after further testing.